It is a subject he has never been shy to tackle head-on.
Now Prince William has joined Katy Perry and other celebrities to record a message on the importance of talking about mental illness.
The minute-long message featuring William with Katy, Stephen Fry and Alesha Dixon will be broadcast across hundreds of UK radio stations on Monday.
Their message will emphasise the importance of talking about mental health, how listening cannot be underestimated, and how each and every one of us has the power to make a difference.
The project marks a collaboration between commercial radio, and Heads Together, the mental health campaign spearheaded by The Royal Foundation – the charity led by William, Kate, Harry and Meghan.
Lorraine Heggessey, chief executive of The Royal Foundation, said: ‘We are so grateful to be working with the radio industry to remind everyone of the power of listening, and let them know about the plethora of mental health volunteering opportunities they can get involved in.’