Manchester United midfielder Paul Pogba and forward Anthony Martial have withdrawn from the France squad for the Nations League match against Holland.
They will also miss the friendly against Uruguay because of injury.
Pogba was absent from the United squad which was beaten 3-1 at Manchester City on Sunday, with Martial completing the full game.
The French Football Federation confirmed neither player would be involved for the world champions over the international break.
A post on the France national team Twitter feed said Pogba’s injury was a thigh problem, while Martial had a groin injury.
Both players had reported to the squad’s base at Clairefontaine and been assessed by Dr Franck Le Gall.
Arsenal forward Alexandre Lacazette and Tottenham midfielder Moussa Sissoko have been called up as replacements by Les Bleus coach Didier Deschamps.
France can secure top spot in Nations League Group A and qualification for the finals when they tackle Holland in Rotterdam on November 16.